AMY DA site - i can understand - tab Improved awareness journey - video 1 inside fragment

It seems your browser is blocking 3rd party cookies which are required to display videos. To resolve this issue, please update your cookie settings to allow these 3rd party cookies.


  • 00:00:15
    Diagnosing AL amyloidosis early,
  • 00:00:18
    it relies on increasing awareness.
  • 00:00:22
    Once you have unexplained nephrotic syndrome
  • 00:00:25
    unexplained congestive heart failure, unintentional weight loss,
  • 00:00:29
    peripheral and autonomic neuropathy, and even acquired Factor X deficiency
  • 00:00:35
    leading to coagulopathy, the suspicion
  • 00:00:39
    for AL amyloidosis should be high.
  • 00:00:47
    The therapeutic landscape for systemic AL amyloidosis
  • 00:00:51
    has changed and expanded dramatically
  • 00:00:55
    in the last 20 years, and that is the span of my career.
  • 00:01:00
    So the treatments are twofold.
  • 00:01:01
    The first is the definitive treatment
  • 00:01:04
    attacking the plasma cell dyscrasia
  • 00:01:07
    and the second treatment is the supportive treatment
  • 00:01:10
    is based on expertise from subspecialties
  • 00:01:15
    to make patients’ quality of life better
  • 00:01:19
    by controlling congestive heart failure
  • 00:01:22
    and nephrotic syndrome and autonomic neuropathy.
  • 00:01:26
    But the treatments that are directed towards
  • 00:01:29
    the plasma cell dyscrasia reduces the production
  • 00:01:32
    of the amyloidogenic light chains to improve the organ dysfunction
  • 00:01:37
    and, hence, improve the outlook and prognosis of patients with AL amyloidosis.
  • 00:01:44
    Even before you start treatment,
  • 00:01:46
    multidisciplinary collaboration is key in figuring out
  • 00:01:50
    if a patient is a candidate for aggressive treatment.
  • 00:01:55
    And I think—we do this every Friday at the Amyloidosis Center
  • 00:01:58
    here where we sit down, and we discuss every patient.
  • 00:02:00
    And Dr. Sanchorawala will ask us as cardiologists
  • 00:02:05
    do you think this patient can tolerate the treatment that I’m thinking of?
  • 00:02:08
    Do you think this patient can tolerate
  • 00:02:10
    aggressive treatment because of their heart involvement?
  • 00:02:13
    So, I think the cardiologist takes a really important role
  • 00:02:16
    in figuring out if a patient is a candidate
  • 00:02:19
    for aggressive anti-plasma cell treatment
  • 00:02:21
    or for modifying that treatment
  • 00:02:24
    so that they are candidates for treatment.
  • 00:02:32
    I’m sort of really impressed by how far we’ve come in this field,
  • 00:02:34
    and I think that there is real promise
  • 00:02:37
    to take this disease that used to be uniformly fatal
  • 00:02:41
    and convert it into more of a chronic disease that we can manage.
  • 00:02:46
    Really the next step in this treatment, in this disease,
  • 00:02:48
    is to figure out how to prevent
  • 00:02:50
    progression of the organs that are involved.
  • 00:02:53
    Remember, that you're working on 2 levels here.
  • 00:02:56
    You're working at the level of a plasma cell dyscrasia
  • 00:02:59
    for bone marrow disorder, but then, this
  • 00:03:02
    amyloid protein is depositing in organs and causing organ failure,
  • 00:03:05
    heart failure, kidney failure, nervous system problems, GI problems.
  • 00:03:10
    I think that’s really where the future is,
  • 00:03:11
    and there's a lot of interesting developing things like that
  • 00:03:14
    when somebody develops signs of organ damage,
  • 00:03:17
    you know, how do you reverse that?
  • 00:03:19
    And I think that is going to be the next frontier for us.