- I See Blood Cancer
Explore the full range of symptoms of AL amyloidosis and the specific symptomatic
manifestations you might come across depending on your specialty.
AL amyloidosis can cause a number of vague symptoms and affect the body in several ways, making it hard to properly diagnose. Over the course of diagnosing this condition, specialists need to be aware of the full constellation of symptoms, look at the patient holistically and collaborate with other specialties involved to avoid potential misdiagnosis or delayed diagnosis.
Broader awareness of the symptoms and greater cross-disciplinary collaboration can help lead to earlier diagnosis and impact the outcomes associated with AL amyloidosis.[1][2][3]
Carpal tunnel syndrome (bilateral)
Access an overview of the symptoms to look for in AL amyloidosis, together with specific symptoms by category.
Low electrocardiographic voltage[3] |
Restrictive cardiac wall thickening[3] |
Late gadolinium enhancement and characteristic T1 mapping at MRI [3] |
hsTnT above normal [3][7] |
BNP = B-type natriuretic peptide; hsTnT = high sensitivity troponin T; MRI = magnetic resonance imaging; NT-proBNP = N terminal pro-B-type natriuretic peptide.
*Where NT-proBNP is not available / in the case of renal impairment.[8]
What should you look for and consider when you suspect AL amyloidosis?
In this short 3-minute video, Dr Omar Siddiqi (cardiology) shares some insightful information on identifying the symptoms of AL amyloidosis.
Frequently observed clinical features | Potential biomarkers |
---|---|
Frequently observed clinical features Nephrotic syndrome, peripheral oedema, ascites, or renal failure[3][9] | Potential biomarkers Total urine protein excretion rate >3,500 mg/day (protein-creatinine ratio>3,000 mg/g), with a decreased serum albumin concentration and oedema, with or without a decrease in glomerular filtration rate[9] |
What should you look for and consider when you suspect AL amyloidosis?
In this short 3-minute video, Dr Vaishali Sanchorawala (haematology/oncology) and Dr Omar Siddiqi (cardiology) share some insightful information on identifying the symptoms of AL amyloidosis.
Frequently observed clinical features | Potential biomarkers |
---|---|
Frequently observed clinical features Hepatomegaly without scan defects[3] | Potential biomarkers Elevated alkaline phosphatase in the absence of other causes [3] |
What should you look for and consider when you suspect AL amyloidosis? In this short 3-minute video, Dr Vaishali Sanchorawala (haematology/oncology) and Dr Omar Siddiqi (cardiology) share some insightful information on identifying the symptoms of AL amyloidosis.
BM=bone marrow; BMI=body mass index; eGFR=estimated glomerular filtration rate; dFLC=difference of involved minus uninvolved FLC; FLC=free light chain; iFLC=involved FLC; MGUS=monoclonal gammopathy of undetermined significance; NT-proBNP=N-terminal pro-B-type natriuretic peptide.
*Where NT-proBNP is not available / in the case of renal impairment[8]
What should you look for and consider when you suspect AL amyloidosis? In this short 4-minute video, Dr Vaishali Sanchorawala (haematology/oncology) and Dr Omar Siddiqi (cardiology) share some insightful information on identifying the symptoms of AL amyloidosis.
What should you look for and consider when you suspect AL amyloidosis? In this short 4-minute video, Dr Vaishali Sanchorawala (haematology/oncology) and Dr Omar Siddiqi (cardiology) share some insightful information on identifying the symptoms of AL amyloidosis.