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Waldenström’s macroglobulinemia

I See Waldenström's macroglobulinemia (WM)

Welcome to I see Waldenström’s macroglobulinemia, a dedicated resource to help healthcare practitioners find the latest information about the signs, symptoms and diagnosis of WM.

What is Waldenström's macroglobulinemia (WM)?

Waldenström’s macroglobulinemia (WM) is a chronic, indolent, B-cell disorder characterised by bone marrow infiltration with lymphoplasmacytic cells, along with IgM monoclonal gammopathy.[1][2]

WM statistics

of Non-Hodgkin lymphomas[3]

Median age of diagnosis[3]

~2x more common in men[3]

Median overall survival[4]

WM incidence rates

In Europe, the WM incidence rate is 7.3 per million in men, and 4.2 per million in women[3]

A strong familial predisposition has been reported,[3][5] first-degree relatives of WM patients have up to 20-fold increased risk for developing WM (and also increased risk but at lower level for other B-cell disorders).[3]

In contrast to multiple myeloma, WM prevalence is higher among Caucasians than other races.[3][6]

Risk factors

The main risk factor for WM is the presence of IgM-monoclonal gammopathy of uncertain significance (MGUS).[7][8] Whilst in most people, MGUS remains stable and doesn’t cause problems or need treatment, there is a risk of MGUS developing into a cancer.[9] The presence of IgM-MGUS increases the risk of WM by 46 times vs. the general population.[10][11]

Other risk factors include:[10][11]:

dna
Genetic predisposition[3][7]
icon
Presence of autoimmune disease[7]
germ
History of infections[7]

WM immunophenotype and genetic mutations

WM cells are characterised by very specific immunophenotypes[3][^7]:

plus

Positive for WM

IgM, CD19, CD20, CD22, CD25, CD27, CD79a

question

Variable for WM

CD5, CD10, CD23, CD138

minus

Negative for WM

CD103

These characteristic immunophenotypes differentiate WM from other Non-Hodgkin lymphomas and from multiple myeloma (MM).[7]

icons

Patients with WM present with different genetic variations, with the most common being del (6q) together with the somatic mutation in MYD88(L265P).[7] The latter has an important role in the growth and survival of WM cells.[1][7]

Learn about the steps involved in diagnosing your patient’s WM

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A dedicated online resource for healthcare professionals to learn about the diagnosis and management of rare haematological malignancies: AL amyloidosis, Waldenström's macroglobulinemia, mantle cell lymphoma and acute myeloid leukaemia.

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macroglobulinemia

CD=cluster of differentiation; IgM=immunoglobulin M; MGUS=monoclonal gammopathy of uncertain significance; WM=Waldenström’s macroglobulinemia.

This site has been developed by Janssen-Cilag International NV. Janssen-Cilag International NV is the responsible editor of this document.

ITEM CODE: CP-231043 | DATE OF PREPARATION: June 2021.