Waldenström’s macroglobulinemia (WM) is a chronic, indolent, B-cell disorder characterised by bone marrow infiltration with lymphoplasmacytic cells, along with IgM monoclonal gammopathy.
Have a look at the International Prognostic Scoring System for Waldenström's Macroglobulinemia (IPSSWM) to evaluate the probability of progression, and its correlation with median survival.
CP-299791, approved on 11/05/2022
WM cells are characterised by very specific immunophenotypes[^7]:
Positive for WM
IgM, CD19, CD20, CD22, CD25, CD27, CD79a
Variable for WM
CD5, CD10, CD23, CD138
Negative for WM
These characteristic immunophenotypes differentiate WM from other Non-Hodgkin lymphomas and from multiple myeloma (MM).
Patients with WM present with different genetic variations, with the most common being del (6q) together with the somatic mutation in MYD88(L265P). The latter has an important role in the growth and survival of WM cells.
CD=cluster of differentiation; IgM=immunoglobulin M; MGUS=monoclonal gammopathy of uncertain significance; WM=Waldenström’s macroglobulinemia.
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