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Greater patient satisfaction of treatment can lead to better adherence, subsequently improving clinical outcomes and QOL[1][2]

Improved clinical outcomes

Improved clinical outcomes

Satisfaction of ART may influence HIV care retention and ART adherence, of which both are key factors of viral suppression (all p<.0001).[3]

Enhanced treatment adherence

In a cohort of nearly 3000 Swedish PLHIV, overall treatment satisfaction was associated with a better ART adherence.[4]

Increased treatment durability

The prescription of a tolerable and convenient ART is a critical step to increase treatment durability.[5]

Although efficacy and tolerability are still cornerstones of treatment satisfaction,[5] the modern era of ART therapy has opened the door for new possibilities to improve the lives of PLHIV

A treatment that reduces the effects of long-term ART use

In a survey of 1085 PLHIV:[6]

  • 73% of respondents on treatment were concerned about the long-term effects of ART
  • One of the most important potential improvements to current regimens was the reduction of these long-term effects (25%)
A treatment that is flexible around individual lifestyles

Daily life is filled with barriers to adherence – unexpected routine changes, hectic schedules, sleeping away from home[7]

In a survey of 1085 PLHIV:[6]

  • A principal recommendation for future ARTs was the potential for a longer lasting treatment

The EACS guidelines agree on simplifying treatment in PLHIV who are virally suppressed[8]

A treatment that considers emotional and social QoL

A patient preferences questionnaire in 218 PLHIV showed that ART should:[9]

  • Support emotional QoL by making their HIV status less obvious to others
  • Maintain their social QoL by allowing them to continue to participate in social activity

Similarly to switching treatment because of physical events,[10] switching treatment due to mental, emotional and social needs can save lives, enhance outcomes,[11][12] and ensure PLHIV have a life worth living

Autonomy is also a key determinant of patient satisfaction[13]


More is needed to tackle the consequences of self-stigma[14]


It may be time to look at the non-clinical adverse events of ART and consider the new possibilities of switching to a treatment that can change the way patients live with HIV

All images are for illustrative purposes only. Any person depicted is a model.

ABBREVIATIONS
ART: antiretroviral therapy; PLHIV: people living with HIV; QoL: quality of life.

References

Casado JL, et al. HIV Med. 2016; 17(1): 46–5.
de Oliveira e Silva AC, et al. Rev Lat Am Enfermagem. 2014; 22(6): 994–1000.
Dang B, et al. PLoS One 2013; 8(1): e54729.
Marrone G, et al. PLoS One 2016; 11(6): e0156916.
Eaton EF, et al. Patients Pref Adherence. 2017; 11: 1585–1190.
Young B, et al. Open Forum Infect Dis. 2017; 4(Suppl 1): S431–S432.
Gilmore HJ, et al. AIDS Patient Care STDs. 2013;27(10): 560–566.
EACS Guidelines 10.0; November 2019.
Mühlbacher AC, et al. Health Econ Rev. 2013; 3(1): 14.
Maiese EM, et al. Curr Med Res Opin. 2016; 32(12): 2039–2046.
Martikainen P, et al. Int J Epidemiol. 2002; 31: 1091–1093.
Harding R, et al. J Acquir Immune Defic Syndr. 2015; 70(5): e176–177.
Ahmed SI, et al. Eur J Pers Cent Healthc. 2017; 5(1): 138–144.
Pantelic M, et al. BMC Infectious Diseases 2019; 19: 210.