Psoriasis rarely appears
on its own

Patients with psoriasis have >50% greater risk for stroke or myocardial infarction compared with the general population.^[2]

Severe psoriasis may be associated with a higher risk of cardiovascular mortality, and patients with psoriasis for more than 8 years may have a higher prevalence of coronary heart disease.^[3][4]

Compared with the general population, people with psoriasis have a 2.9-fold increased risk of developing Crohn's disease.^[5]

People with Crohn's disease have a 7-fold increased risk of developing psoriasis.^[5]

The more severe psoriasis is, the stronger the association with metabolic syndromes, such as central obesity, dyslipidemia, and insulin resistance.^[5]

Weight loss can improve the condition (as obesity may play some role in triggering psoriasis), however, it may not be sufficient alone to control the disease.^[5]

~30% of patients with psoriasis develop PsA in their lifetime^[6], and up to 20% of people with PsA suffer from severe joint deformities.^[5] People with PsA have an increased rate of mortality (+59% in women, +65% in men).^[5]

Skin involvement usually precedes arthritis in 75% of cases, and nail changes are seen in up to 90% of people with PsA.^[5]

Biologics such as IL-23 inhibitors may help improve the condition of your patients with both skin and joints involvement.^[7]

People with psoriasis have a higher prevalence of Obstructive Sleep Apnea/ Hypopnea Syndrome (OSAHS) compared with the general population.^[5]

This association could be due to obesity, although the involvement of inflammatory mediators cannot be excluded.^[5]

~2% of people with psoriasis develop intraocular inflammatory disease, especially uveitis.^[5]

Although not as frequent as other comorbidities, uveitis is insidious and may lead to complications, such as retinal vasculitis, if left untreated.^[5]