MDD profoundly affects the individual, their family and wider society, with effects across quality of life domains including mental health, relationships, functioning, and engagement with activities of daily living.[1]
Several studies have established the overall burden of MDD.[3] In one 12-month prospective study, patients with MDD had a nearly 5-times greater risk of disability compared to asymptomatic individuals.[4]
A longitudinal quality of life study in over 1,000 patients with MDD from France, Germany, Spain, Sweden and the UK reported:[6]
Severely impaired SF-12 mental health score (MCS) in MDD patients compared to other common chronic diseases (MCS 26.5 vs. 50)
A strong association between patient-assessed depression severity (PHQ-9) and quality of life impairment (p<0.001 for SF-12 MCS)
* Quote is adapted from a comprehensive examination of the reported problems and or the questions asked by users of an online depression support forum.[2]
MCS, mental component summary score. MDD, Major depressive disorder. PHQ-9, Patient Health Questionnaire-9. SF-12, 12-Item Short Form Survey.